06 Jan 2013
Familial Mediterranean fever (FMF) is an autoinflammatory disease in MEFV gene mutations and is characterized by recurrent episodes of self-limited fever and local serositis. The complement system is a key regulator of the inflammatory process. The purpose of this study is to investigate the genetic change and C5aR and C5L2 gene attacks FMF patients neutrophil gene expression patterns. Observed in the two receptor gene mutations, while observed in C5aR1 genetic change is determined as N279ķ polymorphic variants. In addition, the C5L2 gene mRNA expression were observed in the neutrophils FMF patients compared with the control group. Binding capacity rhC5a and the ability to generate reactive oxygen species is of similar neutrophils from healthy subjects and FMF patients and independent existence N279ķ polymorphism C5L2 mRNA expression.